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It should be noted that late-life hormone replacement therapy (HRT) is still controversial. In addition to the positive studies, there are also pivotal studies that show negative outcomes. One large study was the women’s health initiative (WHI), which looked at HRT in postmenopausal women and found that risks were greater than benefits. This study has received as much criticism as it has praise. Studies looking at testosterone replacement therapy in men are all over the map in terms of positive vs negative outcomes.
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